Brain and Behavioral Effects of Female-to-Male Gender Transition Treatments

Parents and Patients: If you have not yet started using female-to-male (FtM) drugs, then please click here to read about potentially harmful brain and behavioral effects from the drugs, and click here to learn why those effects may be especially bad for females with autism, psychiatric disorders or hormonal problems such as polycystic ovary syndrome (PCOS). File an FDA Report: If you think that drugs were prescribed inappropriately or if you or your child already suffered problems that might be the result of FtM drug use—such as increased aggression, depression, anxiety, worsened autism symptoms, neurological problems or physical health problems—then please consider filing a report with the U.S. Food & Drug Administration (FDA). Click here for instructions and links to the FDA site where patients can report problems. You are not required to give your child’s full name to the FDA. You do not need to be a U.S. citizen to file a report. You can file a report even if your child is age 18 or older.

This site provides information about the brain and behavioral effects of two types of drugs that are used for female-to-male (FtM) transition:

  • Testosterone drugs (anabolic-androgenic steroids)
  • GnRHa (puberty-blocking) drugs

These drugs are not FDA-approved for gender transition purposes, yet doctors continue to prescribe them to females who often have autism or psychiatric disorders.

Click here to learn why it may be dangerous for females with polycystic ovary syndrome (PCOS) or high testosterone, or autism or psychiatric disorders, to use FtM drugs.

Click here for information about adverse effects that may result from FtM treatments, including

  • Autism symptoms
  • Self-harm and suicide
  • Abnormal brain development
  • Mood swings, delusions, and impaired judgment
  • Schizophrenia, bipolar or borderline personality disorder symptoms
  • Attention deficit hyperactivity disorder (ADHD) symptoms
  • Verbal and IQ deficits
  • Memory problems
  • Neurological disorders and dementia
  • Aggression and anti-social or criminal behaviors

Click here for information on specific testosterone drugs such as Androgel®.

Click here for information on GnRHa drugs/Lupron.

Click here for background information about the gender transition fad.

If you know about a study that should be included, or if you want to provide other information or comments, please email the site editor: